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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
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規(guī)格

庫存

目錄價

會員專享價

數(shù)量

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基本信息

英文名稱	Anti-Human IGF1RxHer3 Bispecific Antibody (Istiratumab; MM 141; MM-005)
中文名稱	艾司妥單抗
CAS號	1509928-04-4

安全信息

產(chǎn)品詳情

Istiratumab, a bispecific mAb against IGF-1R and ErbB3, promotes receptor degradation via proteasomes, inhibiting AKT in pancreatic cancer cells and blocking PI3K/MAPK in ovarian cancer. It enhances chemo efficacy, potentiating paclitaxel, cisplatin, and doxorubicin in preclinical studies.

相關(guān)文獻

Randomized, double-blind, placebo-controlled phase II study of istiratumab (MM-141) plus nab-paclitaxel and gemcitabine versus nab-paclitaxel and gemcitabine in front-line metastatic pancreatic cancer (CARRIE).

PMID: 31912800 DOI: 10.1016/j.annonc.2019.09.004

Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer.

PMID: 29549161 DOI: 10.1158/1078-0432.CCR-17-2262

Dual targeting of IGF-1R and ErbB3 as a potential therapeutic regimen for ovarian cancer.

PMID: 31728045 PMCID: PMC6856132 DOI: 10.1038/s41598-019-53322-y

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