英文名稱 | Anti-Human PCSK9 Monoclonal Antibody(Evolocumab); AMG 145 |
---|---|
中文名稱 | 依洛尤單抗; 依伏庫(kù)單抗 |
CAS號(hào) | 1256937-27-5 |
外觀 | Colorless to light yellow (Solution) |
儲(chǔ)存條件 | Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 |
---|---|---|---|---|
1 mg | 3-5days | ¥3000.00 | 登錄后可見(jiàn) | |
5 mg | 3-5days | ¥12500.00 | 登錄后可見(jiàn) | |
10 mg | 3-5days | ¥20000.00 | 登錄后可見(jiàn) | |
50 mg | 3-5days | ¥80000.00 | 登錄后可見(jiàn) | |
100 mg | 3-5days | ¥125000.00 | 登錄后可見(jiàn) |
英文名稱 | Anti-Human PCSK9 Monoclonal Antibody(Evolocumab); AMG 145 |
---|---|
中文名稱 | 依洛尤單抗; 依伏庫(kù)單抗 |
CAS號(hào) | 1256937-27-5 |
外觀 | Colorless to light yellow (Solution) |
儲(chǔ)存條件 | Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. |
Evolocumab (AMG 145) is a human monoclonal antibody that inhibits PCSK9. Evolocumab is used in the study of hypercholesterolemia and atherosclerotic cardiovascular disease. Evolocumab binds to circulating PCSK9 protein and inhibits its binding to LDLR. Evolocumab has antioxidant and cytoprotective activities against H2O2-induced oxidative damage to endothelial cells. Evolocumab may also negatively regulate activation of the TLR-4/NF-κB signaling pathway to prevent inflammation.