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規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
5 mg	In-stock	￥368.00	登錄后可見	- +
10 mg	In-stock	￥588.00	登錄后可見	- +
25 mg	In-stock	￥1068.00	登錄后可見	- +
50 mg	In-stock	￥1708.00	登錄后可見	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

5 mg

In-stock

￥368.00

登錄后可見

- +

10 mg

In-stock

￥588.00

登錄后可見

- +

25 mg

In-stock

￥1068.00

登錄后可見

- +

50 mg

In-stock

￥1708.00

登錄后可見

- +

基本信息

英文名稱	Carfilzomib (Synonyms: PR-171)
中文名稱	(S)-4-甲基-N-((S)-1-(((S)-4-甲基-1-((R)-2-甲基氧基-2-基)-1-氧代戊烷-2-基)氨基)-1-氧代-3-苯基丙烷-2-基)-2-((S)-2-(2-嗎啉乙酰氨基)-4-苯基丁胺基)戊酰胺;卡非佐米
CAS號(hào)	868540-17-4
分子式	C40H57N5O7
分子量	719.91
MDL	MFCD11040997
外觀	White to off-white powder
儲(chǔ)存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

安全信息

產(chǎn)品詳情

Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM in ANBL-6 cells, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. Carfilzomib activates prosurvival autophagy and induces cell apoptosis.

This product is unstable in solution state. We recommend that you use it immediately.

相關(guān)文獻(xiàn)

Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myeloma.

PMID: 17591945 PMCID: PMC2200918 DOI: 10.1182/blood-2007-01-065888

PMID: 23990113 DOI: 10.1158/1535-7163.MCT-13-0156

PMID: 25972243 DOI: 10.1530/ERC-14-0510

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CL3040

(S)-4-甲基-N-((S)-1-(((S)-4-甲基-1-((R)-2-甲基氧基-2-基)-1-氧代戊烷-2-基)氨基)-1-氧代-3-苯基丙烷-2-基)-2-((S)-2-(2-嗎啉乙酰氨基)-4-苯基丁胺基)戊酰胺;卡非佐米