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塞卡替尼

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Saracatinib (AZD0530)

產(chǎn)品編號(hào)：CL2365 CAS No.：379231-04-6 MDLNo： 分子式：C27H32ClN5O5 分子量：542.03
規(guī)格 庫存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
10 mg In-stock ￥466.00 登錄后可見
- +
25 mg In-stock ￥688.00 登錄后可見
- +
50 mg 3-5days ￥966.00 登錄后可見
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100 mg 3-5days ￥1668.00 登錄后可見
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基本信息
英文名稱 Saracatinib (AZD0530)
中文名稱塞卡替尼
CAS號(hào)379231-04-6
分子式C27H32ClN5O5
分子量542.03
外觀White to light yellow powder
儲(chǔ)存條件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

 Saracatinib, also known as AZD0530, is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities. Src and Abl are protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. Saracatinib binds to and inhibits these tyrosine kinases and their effects on cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival.

Saracatinib (AZD0530) is a potent Src family inhibitor with IC50s of 2.7 to 11 nM for c-Src, Lck, c-YES, Lyn, Fyn, Fgr, and Blk. Saracatinib shows high selectivity over other tyrosine kinases.


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