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成球菌素

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Conglobatin

產(chǎn)品編號：CL1460 CAS No.：72263-05-9 MDLNo： 分子式：C28H38N2O6 分子量：498.61
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
1 mg 3-5days ￥2500.00 登錄后可見
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5 mg 3-5days ￥7500.00 登錄后可見
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基本信息
英文名稱 Conglobatin
中文名稱成球菌素
CAS號72263-05-9
分子式C28H38N2O6
分子量498.61
外觀White to grayish white powder
儲存條件Store at -20°C
產(chǎn)品詳情

Conglobatin is a dimeric macrolide dilactone originally isolated from S. conglobatus. It disrupts binding of heat shock protein 90 (Hsp90) to the co-chaperone Cdc37 complex and induces downregulation of client protein expression in SK-BR-3 breast cancer cells. It also inhibits cell proliferation in HER2+ breast cancer cell lines (IC50s = 12.9-61.5 uM, respectively) and decreases the number of invasive cells in vitro. When combined with lapatinib , tumor growth of SK-BR-3 mouse xenografts was reduced to a greater degree than with conglobatin alone. Conglobatin has various anticancer effects in esophageal squamous cell carcinoma (ESCC) models as well, including an inhibition of cell proliferation in KYSE510 cells (IC50 = 9.31 uM). It also inhibits β1 integrin activation leading to a loss of cellular adhesion.

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